Researchers create new model to better understand, treat metabolic diseases

Credit: Cell Metabolism (2022). DOI: 10.1016/j.cmet.2022.06.003

Although it has been over 100 years since insulin was discovered, metabolic diseases such as diabetes, obesity, and fatty liver still have a significant impact on most people. A staggering 36.5 percent (36.5%) of American adults are obese. Another 32.5 percent (32.5%) are overweight. More than two-thirds (33.5%) of Americans are obese or overweight.

Metabolic syndrome refers to a group of conditions that can occur together and increase one’s risk for heart disease, stroke, and type 2 diabetes. These conditions include high blood sugar, increased blood pressure, excess body fat around one’s waist, abnormal cholesterol and triglyceride levels. These conditions are not easily prevented or reversed, despite extensive experimentation and research.

A group of researchers from Boston University School of Medicine, Yale School of Medicine, and the University of Montreal has created a new testable model to help better understand and treat metabolic diseases.

“Progress requires models to help us understand. The current models are not adequate and will not help solve this important problem. “A revised model is required,” says Barbara E. Corkey (Ph.D.), co-corresponding author and professor emeritus at BUSM in medicine and biochemistry.

This review article focuses on many new aspects of cell metabolism signal transduction. This is the process by which cells respond to substances outside of the cell using signaling molecules located on the surface and inside of the cell. It has been a field that has not received much new knowledge. The researchers have created a new testable model from this analysis.

Researchers claim that this study addresses a fundamental question in metabolism: How do calorigenic nutrients activate cells? This is important not only in the diabetes field, but also in many other systems. [as]Corkey explains that the fuel-sensitive cells of the gut, the portal vein, and the brain are all fuel-sensitive,”

These findings are published online in the journal Cell Metabolism.

Researchers discover a new treatment to treat metabolic syndrome

More information:
Matthew J. Merrins, et al. Metabolic cycles. Signals for insulin secretion. Cell Metabolism (2022). DOI: 10.1016/j.cmet.2022.06.003

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Boston University School of Medicine

Researchers develop new model to better understand and treat metabolic diseases (2022, 21 June)
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