Liver protein protects against stiff arteries in obesity and diabetes

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New research shows the importance and effectiveness of protein adropin to prevent stiffness in the arteries for people with type 2 and obesity. The study was published in advance of print in the journal. American Journal of Physiology – Heart and Circulatory Physiology.

Arterial stiffness is a condition that is related to aging and insulin resistance. It is a chronic condition associated obesity and is a major contributor to the development cardiovascular disease such as stroke and heart attack.

Adropin, a liver protein, plays an important role in maintaining energy balance and sugar metabolism. Studies have shown that adropin may also play a role in maintaining cardiovascular health. Adropin levels in the bloodstream are lower for people with type 2 diabetes and obesity.

Researchers found that patients undergoing bariatric surgery had lower liver expression and higher body mass. A separate study found that type 2 diabetes patients had lower levels of adropin and higher arterial stiffness than healthy controls.

The researchers also studied isolated arteries from mice lacking adropin. They reported that “loss” of adropin alone causes arterial stiffness to increase, similar to the effects of type 2 diabetes and obesity. Later, the researchers used adropin to treat arterial stiffening using a mouse model of obesity/type 2 diabetes. They found that “adropin exposure reduces obesity-associated arterial stiffening.”

These findings indicate that people who have low levels of adropin may be more susceptible to arterial stiffening. As such, it is important to consider adropin as a therapeutic target in the prevention and treatment for cardiovascular disease in people with type 2 and obesity.

Study shows a link between carbohydrate intake and adropin

More information:
Thomas J. Jurrissen, et al. Role of adropin for arterial stiffening associated obesity and type-2 diabetes. American Journal of Physiology – Heart and Circulatory Physiology (2022). DOI: 10.1152/ajpheart.00385.2022

Provided by
American Physiological Society

Liver protein protects against stiffarteries in obesity or diabetes (2022, September 20).
Retrieved 20 September 2022
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